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dc.creatorCatalano, C.en
dc.creatorGoodship, T.H.J.en
dc.creatorGraham, K.A.en
dc.creatorMarino, C.en
dc.creatorBrown, A.L.en
dc.creatorTapson, J.S.en
dc.creatorWard, M.K.en
dc.creatorWilkinson, R.en
dc.date.accessioned2015-05-05T19:03:21Zen
dc.date.available2015-05-05T19:03:21Zen
dc.date.created1996-01en
dc.date.issued1996-01en
dc.identifier10.1093/oxfordjournals.ndt.a027028en
dc.identifier.bibliographicCitationNephrology, Dialysis, Transplantation. 1996 Jan; 11(1): 133-139.en
dc.identifier.issn0931-0509en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Withdrawal+of+Renal+Replacement+Therapy+in+Newcastle+upon+Tyne:+1964-1993&title=Nephrology,+Dialysis,+Transplantation.++&volume=11&issue=1&pages=133-139&date=1996&au=Catalano,+C.en
dc.identifier.urihttp://dx.doi.org/10.1093/oxfordjournals.ndt.a027028en
dc.identifier.urihttp://hdl.handle.net/10822/754575en
dc.description.abstractBACKGROUND. Termination of renal replacement therapy (RRT) is common in North America and Australia but is considered to be rare in Europe. METHODS. In order to review the phenomenon of RRT termination in all patients treated in Newcastle upon Tyne between 1964 and 1993 a retrospective study of clinical case notes was undertaken. In all RRT patients sex, age at start of RRT, renal diagnosis and history of RRT were recorded. In addition, mortality data and marital and residential status were recorded in all patients who died, and Karnofsky index, bodyweight, complications, history of bereavement, place of death, overall survival, survival after withdrawal of treatment, other medical problems, higher mental function and surgical history in all patients stopping treatment. RESULTS. 1639 patients started RRT between 1964 and September 1993 inclusive. Eighty-eight patients were identified in whom death was a result of treatment being stopped (17% of all deaths). The first was in 1985. In these patients, age was greater (62 vs 47 years, P less than 0.001) and diabetes was more prevalent (15 vs 7%, P less than 0.03) than in the total RRT population. The Karnofsky index was 70 at the start and 33 at withdrawal of treatment (P less than 0.001). The Karnofsky index at the start of RRT was weakly related to that at withdrawal and overall survival (r = 0.36 and 0.28 respectively, P less than 0.01). The Karnofsky index at treatment withdrawal correlated with the following survival (r = 0.40, P less than 0.001). The median survival of patients stopping treatment was significantly lower than in all RRT patients (16 vs 74 months, P less than 0.001) and the majority survived less than 2 years. After dialysis withdrawal the median survival was 8 days, 15 patients survived 3 days or less and 19 more than 10 days. The majority (80%) received terminal care in hospital. At treatment withdrawal 11 patients were demented and 34 showed signs of early dementia. Seventy-eight patients (89%) stopped treatment as a consequence of multiple medical problems. The possibility of dialysis withdrawal was raised by physicians in 50.5%, the patient in 23.8% and the patients' relatives in 21.9% of cases. Four patients (3.8%) committed suicide. CONCLUSIONS. Death from dialysis termination is a relatively common cause of death in RRT patients in Newcastle upon Tyne. These patients are older with a higher prevalence of diabetes. In 89% of cases the decision to stop treatment was related to multiple medical problems with a recent deterioration. Physicians raised the issue of withdrawal in the majority of cases and most patients subsequently received terminal care in hospital.en
dc.formatArticleen
dc.languageenen
dc.sourceBRL:MEDKIE/96221647en
dc.subjectAge Factorsen
dc.subjectAllowing to Dieen
dc.subjectBiomedical Technologiesen
dc.subjectChronically Illen
dc.subjectCommunicationen
dc.subjectDeathen
dc.subjectDecision Makingen
dc.subjectDementiaen
dc.subjectDepressive Disorderen
dc.subjectDiabetesen
dc.subjectDiagnosisen
dc.subjectFamily Membersen
dc.subjectHospitalsen
dc.subjectInstitutional Policiesen
dc.subjectKidney Diseasesen
dc.subjectLifeen
dc.subjectMethodsen
dc.subjectMorbidityen
dc.subjectMortalityen
dc.subjectPatientsen
dc.subjectPhysiciansen
dc.subjectPrevalenceen
dc.subjectQuality of Lifeen
dc.subjectRenal Dialysisen
dc.subjectReviewen
dc.subjectRelativesen
dc.subjectStatisticsen
dc.subjectSuicideen
dc.subjectSurveyen
dc.subjectTerminal Careen
dc.subjectTreatment Refusalen
dc.titleWithdrawal of Renal Replacement Therapy in Newcastle Upon Tyne: 1964-1993en
dc.provenanceDigital citation created by the National Reference Center for Bioethics Literature at Georgetown University for the BIOETHICSLINE database, part of the Kennedy Institute of Ethics' Bioethics Information Retrieval Project funded by the United States National Library of Medicine.en
dc.provenanceDigital citation migrated from OpenText LiveLink Discovery Server database named NBIO hosted by the Bioethics Research Library to the DSpace collection BioethicsLine hosted by Georgetown University.en


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