Resource Utilization in Liver Transplantation: Effects of Patient Characteristics and Clinical Practice
Katz, Patricia P.
Lake, John R.
Brown, Robert S.
Dudley, R. Adams
Wiesner, Russell H.
Zetterman, Rowen K.
JAMA. 1999 Apr 21; 281(15): 1381-1386.
CONTEXT: Liver transplantation is among the most costly of medical services, yet few studies have addressed the relationship between the resources utilized for this procedure and specific patient characteristics and clinical practices. OBJECTIVE: To assess the association of pretransplant patient characteristics and clinical practices with hospital resource utilization. DESIGN: Prospective cohort of patients who received liver transplants between January 1991 and July 1994. SETTING: University of California, San Francisco; Mayo Clinic, Rochester, Minn; and the University of Nebraska, Omaha. PATIENTS: Seven hundred eleven patients who received single-organ liver transplants, were at least 16 years old, and had nonfulminant liver disease. MAIN OUTCOME MEASURE: Standardized resource utilization derived from a database created by matching all services to a single price list. RESULTS: Higher adjusted resource utilization was associated with donor age of 60 years or older (28% [$53813] greater mean resource utilization; P=.005); recipient age of 60 years or older (17% [$32795]; P=.01); alcoholic liver disease (26% [$49596]; P=.002); Child-Pugh class C (41% [$67 658]; P less than .001); care from the intensive care unit at time of transplant (42% [$77833]; P less than .001); death in the hospital (35% [$67 076]; P less than .001); and having multiple liver transplants during the index hospitalization (154% increase [$474 740 vs $186 726 for 1 transplant]; P less than .001). Adjusted length of stay and resource utilization also differed significantly among transplant centers. CONCLUSIONS: Clinical, economic, and ethical dilemmas in liver transplantation are highlighted by these findings. Recipients who were older, had alcoholic liver disease, or were severely ill were the most expensive to treat; this suggests that organ allocation criteria may affect transplant costs. Clinical practices and resource utilization varied considerably among transplant centers; methods to reduce variation in practice patterns, such as clinical guidelines, might lower costs while maintaining quality of care.
Adults; Age Factors; Alcohol Abuse; Biomedical Technologies; Comparative Studies; Death; Disease; Economics; Evaluation; Guidelines; Health; Health Care; Hospitals; Intensive Care Units; Illness; Livers; Liver Transplantation; Methods; Organ Transplantation; Patients; Resource Allocation; Review; Selection for Treatment; Tissue Transplantation; Transplant Recipients; Transplantation;
National Institute of Diabetes and Digestive and Kidney Diseases. Liver Transplantation Database Group
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Resource Utilization in Liver Transplantation: Effects of Patient Characteristics and Clinical Practice Showstack, Jonathan; Katz, Patricia P.; Lake, John R.; Brown, Robert S.; Dudley, R. Adams; Belle, Steven; Wiesner, Russell H.; Everhart, James; Zetterman, Rowen K. (National Institute of Diabetes and Digestive and Kidney Diseases. Liver Transplantation Database Group, 1999-04-14)