Ethical Issues in the Design and Conduct of Cluster Randomised Controlled Trials
Edwards, Sarah J.L.
Braunholtz, David A.
Lilford, Richard J.
Stevens, Andrew J.
BMJ (British Medical Journal). 1999 May 22; 318(7195): 1407-1409.
In most randomised controlled trials, individual patients are randomised to a treatment or control group, but sometimes this is undesirable or even impossible and groups (clusters) of people may be randomised instead. These are called cluster randomised controlled trials, and although they have been around for a long time, the need for them is likely to increase in line with growing concern to evaluate the delivery of health services, public education, and policy on social care.
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