Treatment Trials and Their Design
Clinics in Gastroenterology 1978 September; 7(3): 583-594
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The Importance of the Preservation of the Ethical Principle of Equipoise in the Design of Clinical Trials: Relative Impact of the Methodological Quality Domains on the Treatment Effect in Randomized Controlled Trials Djulbegovic, Benjamin; Cantor, Alan; Clarke, Mike (2003-10)Previous research has identified methodological problems in the design and conduct of randomized trials that could, if left unaddressed, lead to biased results. In this report we discuss one such problem, inadequate control ...
Clinical and Prophylactic Trials With Assured New Treatment for Those at Greater Risk: I. a Design Proposal Finkelstein, Michael O.; Levin, Bruce; Robbins, Herbert (1996-05)OBJECTIVES: The accepted sine qua non for estimating the difference in efficacy between a new and a standard treatment is a randomized controlled clinical trial. Yet in some situations it is either practically or ...
Improving Design and Conduct of Randomised Trials by Embedding Them in Qualitative Research: ProtecT (Prostate Testing for Cancer and Treatment) Study Donovan, Jenny; Mills, Nicola; Smith, Monica; Brindle, Lucy; Jacoby, Ann; Peters, Tim; Frankel, Stephen; Neal, David; Hamdy, Freddie (2002-10-05)PROBLEM: Recruitment to randomised trials is often difficult, and many important trials are not mounted because recruitment is thought to be "impossible." DESIGN: Controversial ProtecT (prostate testing for cancer and ...