Randomized Versus Historical Controls for Clinical Trials
Chalmers, Thomas C.
Smith, Harry, Jr.
American Journal of Medicine 1982 February; 72(2): 233-240
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Chalmers, Thomas C.; Celano, Paul; Sacks, Henry S.; Smith, Harry (1983-12-01)The suggestion that bias in the assignment of patients to treatment or control groups may be an important determinant of the outcome of clinical trials was studied through a statistical analysis of 145 papers on controlled trials ...