Statistical and Ethical Issues in Monitoring Clinical Trials
Pocock, Stuart J.
Statistics in Medicine 1993 August; 12(15-16): 1459-1469
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DeMets, David L.; Pocock, Stuart J.; Julian, Desmond G. (1999-12-04)Randomised clinical trials are undertaken in the hope of showing positive benefits of a new treatment, but on occasion quite the opposite trend can occur, If the interim data suggest possible negative (harmful) effects ...