Assessing the Quality of Randomized Controlled Trials: Quality of Design Is Not the Only Relevant Variable
Berk, Paul D.
Sacks, Henry S.
Hepatology 1999 November; 30(5): 1332-1334
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Chalmers, Thomas C.; Celano, Paul; Sacks, Henry S.; Smith, Harry (1983-12-01)The suggestion that bias in the assignment of patients to treatment or control groups may be an important determinant of the outcome of clinical trials was studied through a statistical analysis of 145 papers on controlled trials ...
The Importance of the Preservation of the Ethical Principle of Equipoise in the Design of Clinical Trials: Relative Impact of the Methodological Quality Domains on the Treatment Effect in Randomized Controlled Trials Djulbegovic, Benjamin; Cantor, Alan; Clarke, Mike (2003-10)Previous research has identified methodological problems in the design and conduct of randomized trials that could, if left unaddressed, lead to biased results. In this report we discuss one such problem, inadequate control ...