The Agonising Negative Trend in Monitoring of Clinical Trials
DeMets, David L.
Pocock, Stuart J.
Julian, Desmond G.
Lancet 1999 December 4; 354(9194): 1983-1988
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DeMets, David L.; Pocock, Stuart J.; Julian, Desmond G. (1999-12-04)Randomised clinical trials are undertaken in the hope of showing positive benefits of a new treatment, but on occasion quite the opposite trend can occur, If the interim data suggest possible negative (harmful) effects ...
DeMets, David; Califf, Robert; Dixon, Dennis; Ellenberg, Susan; Fleming, Thomas; Held, Peter; Julian, Desmond; Kaplan, Richard; Levine, Robert; Neaton, James; Packer, Milton; Pocock, Stuart; Rockhold, Frank; Seto, Belinda; Siegel, Jay; Snapinn, Steve; Stump, David; Temple, Robert; Whitley, Richard (2004)