Comparing Drug Effectiveness at Health Plans: The Ethics of Cluster Randomized Trials
Sabin, James E.
Goff, Sarah L.
Hastings Center Report 2008 September-October; 38(5): 39-48
"Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.
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