Industry-Sponsored Ghostwriting in Clinical Trial Reporting: A Case Study
McHenry, Leemon B.
Jureidini, Jon N.
Accountability in Research 2008 July-September; 15(3): 152-167
In this case study from litigation, we show how ghostwriting of clinical trial results can contribute to the manipulation of data to favor the study medication. Study 329 for paroxetine pediatric use was negative for efficacy and positive for harm. Yet the ghostwritten publication from this study concluded that paroxetine provided evidence of efficacy and safety and continues to be influential. Despite the role of named authors in revisions of the manuscript, the sponsor company remained in control of the message.
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Pyke, Stephen; Julious, Steven A; Day, Simon; O'Kelly, Michael; Todd, Susan; Matcham, James; Seldrup, Jorgen (2011-01)Concerns about potentially misleading reporting of pharmaceutical industry research have surfaced many times. The potential for duality (and thereby conflict) of interest is only too clear when you consider the sums of ...
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