Rigor in Monitoring Clinical Trials Is Ethical
Journal of Clinical Oncology 2008 February 1; 26(4): 683-685
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Williams, George W.; Davis, Robert L.; Getson, Albert J.; Gould, A. Lawrence; Hwang, Irving K.; Matthews, Holly; Shih, Weichung Joseph; Snapinn, Steven M.; Walton-Bowen, Karen L. (1993-03)
Goodman, Steven N. (2007-06-19)This commentary reviews the argument that clinical trials with data monitoring committees that use statistical stopping guidelines should generally not be stopped early for large observed efficacy differences because ...