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dc.creatorGoodman, Steven N.en
dc.date.accessioned2016-01-08T23:20:53Zen
dc.date.available2016-01-08T23:20:53Zen
dc.date.created2007-06-19en
dc.date.issued2007-06-19en
dc.identifierdoi:10.7326/0003-4819-146-12-200706190-00010en
dc.identifier.bibliographicCitationAnnals of Internal Medicine 2007 June 19; 146(12): 882-887en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Stopping+at+nothing?+Some+dilemmas+of+data+monitoring+in+clinical+trials&title=Annals+of+Internal+Medicine+&volume=146&issue=12&date=2007-06&au=Goodman,+Steven+N.en
dc.identifier.urihttp://dx.doi.org/10.7326/0003-4819-146-12-200706190-00010en
dc.identifier.urihttp://hdl.handle.net/10822/963868en
dc.description.abstractThis commentary reviews the argument that clinical trials with data monitoring committees that use statistical stopping guidelines should generally not be stopped early for large observed efficacy differences because efficacy estimates may be exaggerated and there is minimal information on treatment harms. Overall, the average of estimates from trials that use these boundaries differs minimally from the true value. Estimates from a given trial that seem implausibly high can be moderated by using Bayesian methods. Data monitoring committees are not ethically required to precisely estimate a large efficacy difference if that difference differs convincingly from zero, and the requirement to detect harms and balance efficacy against harm depends on whether the nature of the harm is known or unknown before the trial.en
dc.formatArticleen
dc.languageenen
dc.sourceeweb:307786en
dc.subjectClinical Trialsen
dc.subjectData Monitoring Committeesen
dc.subjectGuidelinesen
dc.subjectHarmen
dc.subjectMethodsen
dc.subjectNatureen
dc.subject.classificationSociology of Health Careen
dc.subject.classificationHuman Experimentation Policy Guidelines / Institutional Review Boardsen
dc.titleStopping at Nothing? Some Dilemmas of Data Monitoring in Clinical Trialsen
dc.provenanceCitation prepared by the Library and Information Services group of the Kennedy Institute of Ethics, Georgetown University for the ETHXWeb database.en
dc.provenanceCitation migrated from OpenText LiveLink Discovery Server database named EWEB hosted by the Bioethics Research Library to the DSpace collection EthxWeb hosted by DigitalGeorgetown.en


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