Paying Clinical Research Participants: One Institution's Research Ethics Committees' Perspective
Ripley, Elizabeth B.D.
Macrina, Frank L.
Journal of Empirical Research on Human Research Ethics 2006 December; 1(4): 37-44
REGULATORY GUIDELINES LEAVE determination of coercion and undue influence of research participants open to interpretation. A web-based survey was conducted of the research ethics committees members at Virginia Commonwealth University (VCU) to evaluate their perspectives on paying participants in clinical research via general questions, as well as 8 short cases involving hypertension placebo-controlled trials, a pilot exercise study, a survey of substance abusers, a healthy-volunteer pharmacokinetic study, a twin study involving DNA samples, and an asthma medication study in children. Research ethics committee members were asked to state what payment they would consider appropriate for a given type of protocol. The results suggest that risk, time required, reimbursement for expenses, and inconvenience were important in determining appropriate payment, while income and funding source were not. The case studies revealed wide variation in recommended payments both within type of study and between studies.
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Ripley, Elizabeth; Macrina, Francis; Markowitz, Monika; Gennings, Chris (2010-09)Although compensation for expenses to participants in research projects is considered important and the primary reason for paying, there is no evidence to support that investigators and IRB members actually calculate ...
Ripley, Elizabeth; Macrina, Francis; Markowitz, Monika; Gennings, Chris (2010-09)The principle that payment to participants should not be undue or coercive is the consensus of international and national guidelines and ethical debates; however, what this means in practice is unclear. This study determined ...
Ripley, Elizabeth B.D. (2006-12)CURRENT REGULATORY GUIDELINES REQUIRE the ethical review committee to consider one question when evaluating payment: Is the payment to the participant undue or coercive? Although this is a seemingly simple question, ...