What Determines Whether Patients Are Willing to Participate in Resuscitation Studies Requiring Exception From Informed Consent?
Journal of Medical Ethics 2006 August; 32(8): 468-472
OBJECTIVES: To examine the willingness of patients to participate in a resuscitation study that requires exception from informed consent and to determine if willingness to participate is associated with demographic and other characteristics. METHODS: Adult patients in an emergency department and in a geriatric outpatient clinic were surveyed. Patients were asked to imagine that they presented to an emergency department with cardiac arrest and asked about their willingness to (1) receive a new drug outside of a study, (2) receive a new drug as part of a study and (3) participate in a randomised controlled trial (RCT) for a new drug. Patients were also asked about participation in studies of invasive procedures. RESULTS: 213 patients from a geriatric clinic and 207 from an emergency department were surveyed. Two thirds of patients from the geriatric clinic and 83% from the emergency department were willing to receive an experimental drug outside of a study. Patients were less willing to participate in a study of the new drug and even less likely to participate in an RCT for the new drug (chi(2) test for trend, p
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Implementing Emergency Research Requiring Exception From Informed Consent, Community Consultation, and Public Disclosure Salzman, Joshua G.; Frascone, Ralph J.; Godding, Bobette K.; Provo, Terry A.; Gertner, Elie (2007-10)