Current Controversies in Data Monitoring for Clinical Trials
Pocock, Stuart J.
Clinical Trials 2006; 3(6): 513-521
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DeMets, David L.; Pocock, Stuart J.; Julian, Desmond G. (1999-12-04)Randomised clinical trials are undertaken in the hope of showing positive benefits of a new treatment, but on occasion quite the opposite trend can occur, If the interim data suggest possible negative (harmful) effects ...