Quantitative Aspects of Informed Consent: Considering the Dose Response Curve When Estimating Quantity of Information
Journal of Medical Ethics 2005 December; 31(12): 736-738
Information is usually supposed to be a prerequisite for people making decisions on whether or not to participate in a clinical trial. Previously conducted studies and research ethics scandals indicate that participants have sometimes lacked important pieces of information. Over the past few decades the quantity of information believed to be adequate has increased significantly, and in some instances a new maxim seems to be in place: the more information, the better the ethics in terms of respecting a participant's autonomy. The authors hypothesise that the dose- response curve from pharmacology or toxicology serves as a model to illustrate that a large amount of written information does not equal optimality. Using the curve as a pedagogical analogy when teaching ethics to students in clinical sciences, and also in engaging in dialogue with research institutions, may promote reflection on how to adjust information in relation to the preferences of individual participants, thereby transgressing the maxim that more information means better ethics.
Showing items related by title, author, creator and subject.
Motivating donors to genetic research? Anthropological reasons to rethink the role of informed consent Hoeyer, Klaus; Lynoe, Niels (2006)In this article we explore the contribution from social anthropology to the medical ethical debates about the use of informed consent in research, based on blood samples and other forms of tissue. The article springs from ...
Informed Consent for Phase I Studies: Evaluation of Quantity and Quality of Information Provided to Patients Tomamichel, M.; Sessa, C.; Herzig, S.; de Jong, J.; Pagani, O.; Willems, Y.; Cavalli, F. (1995-04)BACKGROUND: The process by which patients are informed and their consent is obtained in phase I trials has thus far been only marginally studied. Since 1986 we have followed an oral procedure, consisting of three consecutive ...