Vertebroplasty and the Randomized Study: Where Science and Ethics Collide
Wagner, Andrew L.
AJNR: American Journal of Neuroradiology 2005 August; 26(7): 1610-1611
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Non-Inferiority Randomized Trials, an Issue Between Science and Ethics: The Case of the SYNTAX Study Mantovani, Vittorio; Lepore, Vincenzo; Mira, Antonietta; Berglin, Eva (2010-12)Non-inferiority trials are questionable when death and serious complications are included among outcomes. The term itself "non-inferiority" is misleading, since such a study would not demonstrate that a new treatment is ...