Pro/con Clinical Debate: It Is Acceptable to Stop Large Multicentre Randomized Controlled Trials at Interim Analysis for Futility. Con: The Hazards of Stopping for Futility
Meade, Maureen O.
Critical Care 2005 February; 9(1): 34-36
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Montori, Victor M.; Devereaux, P.J.; Adhikari, Neill K.J.; Burns, Karen E.A.; Eggert, Christoph H.; Briel, Matthias; Lacchetti, Christina; Leung, Teresa W.; Darling, Elizabeth; Bryant, Dianne M.; Bucher, Heiner C.; Schunemann, Holger J.; Meade, Maureen O.; Cook, Deborah J.; Erwin, Patricia J.; Sood, Amit; Sood, Richa; Lo, Benjamin; Thompson, Carly A.; Zhou, Qi; Mills, Edward; Guyatt, Gordon H. (2005-11-02)CONTEXT: Randomized clinical trials (RCTs) that stop earlier than planned because of apparent benefit often receive great attention and affect clinical practice. Their prevalence, the magnitude and plausibility of their ...