Equipoise, Design Bias, and Randomized Controlled Trials: The Elusive Ethics of New Drug Development
Fries, James F.
Arthritis Research and Therapy 2004; 6(3): R250-R255
Showing items related by title, author, creator and subject.
The Importance of the Preservation of the Ethical Principle of Equipoise in the Design of Clinical Trials: Relative Impact of the Methodological Quality Domains on the Treatment Effect in Randomized Controlled Trials Djulbegovic, Benjamin; Cantor, Alan; Clarke, Mike (2003-10)Previous research has identified methodological problems in the design and conduct of randomized trials that could, if left unaddressed, lead to biased results. In this report we discuss one such problem, inadequate control ...
Ethics and Equipoise: Rationale for a Placebo-Controlled Study Design of Platelet Glycoprotein IIB/IIIa Inhibition in Coronary Intervention Tcheng, James E.; Madan, Mina; O'Shea, J. Conor; Cohen, Eric A.; Buller, Christopher E.; Lincoff, A. Michael; Popma, Jeffrey J.; Teirstein, Paul S.; Kitt, Michael M.; Lorenz, Todd J.; Greenberg, Sally; Fost, Norman; Califf, Robert M.; The ESPRIT Investigators (2003-04)