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dc.creatorDjulbegovic, Benjaminen
dc.creatorCantor, Alanen
dc.creatorClarke, Mikeen
dc.date.accessioned2016-01-09T00:08:23Zen
dc.date.available2016-01-09T00:08:23Zen
dc.date.created2003-10en
dc.date.issued2003-10en
dc.identifierdoi:10.1080/714906103en
dc.identifier.bibliographicCitationAccountability in Research 2003 October-December; 10(4): 301- 315en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=The+importance+of+the+preservation+of+the+ethical+principle+of+equipoise+in+the+design+of+clinical+trials:+relative+impact+of+the+methodological+quality+domains+on+the+treatment+effect+in+randomized+controlled+trials&title=Accountability+in+Research+&volume=10&issue=4&spage=315&date=2003-10&au=Djulbegovic,+Benjamin;+Cantor,+Alan;+Clarke,+Mikeen
dc.identifier.urihttp://dx.doi.org/10.1080/714906103en
dc.identifier.urihttp://hdl.handle.net/10822/997625en
dc.description.abstractPrevious research has identified methodological problems in the design and conduct of randomized trials that could, if left unaddressed, lead to biased results. In this report we discuss one such problem, inadequate control intervention, and argue that it can be by far the most important design characteristic of randomized trials in overestimating the effect of new treatments. Current guidelines for the design and reporting of randomized trials, such as the Consolidated Standards of Reporting Trials (CONSORT) statement, do not address the choice of the comparator intervention. We argue that an adequate control intervention can be selected if people designing a trial explicitly take into consideration the ethical principle of equipoise, also known as "the uncertainty principle."en
dc.formatArticleen
dc.languageenen
dc.sourceeweb:263583en
dc.subjectClinical Trialsen
dc.subjectGuidelinesen
dc.subjectResearchen
dc.subjectRandomized Controlled Trialsen
dc.subjectReportingen
dc.subjectStandardsen
dc.subjectUncertaintyen
dc.subject.classificationHuman Experimentation Policy Guidelines / Institutional Review Boardsen
dc.subject.classificationSocial Control of Human Experimentationen
dc.titleThe Importance of the Preservation of the Ethical Principle of Equipoise in the Design of Clinical Trials: Relative Impact of the Methodological Quality Domains on the Treatment Effect in Randomized Controlled Trialsen
dc.provenanceCitation prepared by the Library and Information Services group of the Kennedy Institute of Ethics, Georgetown University for the ETHXWeb database.en
dc.provenanceCitation migrated from OpenText LiveLink Discovery Server database named EWEB hosted by the Bioethics Research Library to the DSpace collection EthxWeb hosted by DigitalGeorgetown.en


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